GrippeEspagneV1, Main, Exploration, bibRecord, 000391

Pandemic influenza 1918 H1N1 and 1968 H3N2 DNA vaccines induce cross-reactive immunity in ferrets against infection with viruses drifted for decades.

Identifieur interne : 000391 ( Main/Exploration ); précédent : 000390; suivant : 000392

Pandemic influenza 1918 H1N1 and 1968 H3N2 DNA vaccines induce cross-reactive immunity in ferrets against infection with viruses drifted for decades.

Auteurs : Karoline Bragstad [Danemark] ; Cyril J. Martel ; Joakim S. Thomsen ; Kim L. Jensen ; Lars P. Nielsen ; Bent Aasted ; Anders Fomsgaard

Source :

Influenza and other respiratory viruses [ 1750-2659 ] ; 2011.

RBID : pubmed:21138536

Descripteurs français

KwdFr :
- Animaux (MeSH), Anticorps antiviraux (immunologie), Espagne (épidémiologie), Furets (immunologie), Furets (virologie), Grippe humaine (immunologie), Grippe humaine (prévention et contrôle), Grippe humaine (virologie), Grippe humaine (épidémiologie), Hong Kong (épidémiologie), Humains (MeSH), Modèles animaux de maladie humaine (MeSH), Pandémies (MeSH), Protéines virales (administration et posologie), Protéines virales (génétique), Protéines virales (immunologie), Réactions croisées (MeSH), Sous-type H1N1 du virus de la grippe A (génétique), Sous-type H1N1 du virus de la grippe A (immunologie), Sous-type H3N2 du virus de la grippe A (génétique), Sous-type H3N2 du virus de la grippe A (immunologie), Vaccination (MeSH), Vaccins antigrippaux (administration et posologie), Vaccins antigrippaux (génétique), Vaccins antigrippaux (immunologie), Vaccins à ADN (administration et posologie), Vaccins à ADN (génétique), Vaccins à ADN (immunologie).
MESH :
- administration et posologie : Protéines virales, Vaccins antigrippaux, Vaccins à ADN.
- génétique : Protéines virales, Sous-type H1N1 du virus de la grippe A, Sous-type H3N2 du virus de la grippe A, Vaccins antigrippaux, Vaccins à ADN.
- immunologie : Anticorps antiviraux, Furets, Grippe humaine, Protéines virales, Sous-type H1N1 du virus de la grippe A, Sous-type H3N2 du virus de la grippe A, Vaccins antigrippaux, Vaccins à ADN.
- prévention et contrôle : Grippe humaine.
- virologie : Furets, Grippe humaine.
- épidémiologie : Espagne, Grippe humaine, Hong Kong.
- Animaux, Humains, Modèles animaux de maladie humaine, Pandémies, Réactions croisées, Vaccination.
Wicri :
- geographic : Hong Kong, Espagne.

English descriptors

KwdEn :
- Animals (MeSH), Antibodies, Viral (immunology), Cross Reactions (MeSH), Disease Models, Animal (MeSH), Ferrets (immunology), Ferrets (virology), Hong Kong (epidemiology), Humans (MeSH), Influenza A Virus, H1N1 Subtype (genetics), Influenza A Virus, H1N1 Subtype (immunology), Influenza A Virus, H3N2 Subtype (genetics), Influenza A Virus, H3N2 Subtype (immunology), Influenza Vaccines (administration & dosage), Influenza Vaccines (genetics), Influenza Vaccines (immunology), Influenza, Human (epidemiology), Influenza, Human (immunology), Influenza, Human (prevention & control), Influenza, Human (virology), Pandemics (MeSH), Spain (epidemiology), Vaccination (MeSH), Vaccines, DNA (administration & dosage), Vaccines, DNA (genetics), Vaccines, DNA (immunology), Viral Proteins (administration & dosage), Viral Proteins (genetics), Viral Proteins (immunology).
MESH :
- chemical , administration & dosage : Influenza Vaccines, Vaccines, DNA, Viral Proteins.
- chemical , genetics : Influenza Vaccines, Vaccines, DNA, Viral Proteins.
- chemical , immunology : Antibodies, Viral, Influenza Vaccines, Vaccines, DNA, Viral Proteins.
- geographic , epidemiology : Hong Kong, Spain.
- epidemiology : Influenza, Human.
- genetics : Influenza A Virus, H1N1 Subtype, Influenza A Virus, H3N2 Subtype.
- immunology : Ferrets, Influenza A Virus, H1N1 Subtype, Influenza A Virus, H3N2 Subtype, Influenza, Human.
- prevention & control : Influenza, Human.
- virology : Ferrets, Influenza, Human.
- Animals, Cross Reactions, Disease Models, Animal, Humans, Pandemics, Vaccination.

Abstract

BACKGROUND

Alternative influenza vaccines and vaccine production forms are needed as the conventional protein vaccines do not induce broad cross-reactivity against drifted strains. Furthermore, fast vaccine production is especially important in a pandemic situation, and broader vaccine reactivity would diminish the need for frequent change in the vaccine formulations.

OBJECTIVE

In this study, we compared the ability of pandemic influenza DNA vaccines to induce immunity against distantly related strains within a subtype with the immunity induced by conventional trivalent protein vaccines against homologous virus challenge.

METHODS

Ferrets were immunised by particle-mediated epidermal delivery (gene gun) with DNA vaccines based on the haemagglutinin (HA) and neuraminidase (NA) and/or the matrix (M) and nucleoprotein genes of the 1918 H1N1 Spanish influenza pandemic virus or the 1968 H3N2 Hong Kong influenza pandemic virus. The animals were challenged with contemporary H1N1 or H3N2 viruses.

RESULTS

We demonstrated that DNA vaccines encoding proteins of the original 1918 H1N1 pandemic virus induced protective cross-reactive immune responses in ferrets against infection with a 1947 H1N1 virus and a recent 1999 H1N1 virus. Similarly, a DNA vaccine, based on the HA and NA of the 1968 H3N2 pandemic virus, induced cross-reactive immune responses against a recent 2005 H3N2 virus challenge.

CONCLUSIONS

DNA vaccines based on pandemic or recent seasonal influenza genes induced cross-reactive immunity against contemporary virus challenge as good as or superior to contemporary conventional trivalent protein vaccines. This suggests a unique ability of influenza DNA to induce cross-protective immunity against both contemporary and long-time drifted viruses.

DOI: 10.1111/j.1750-2659.2010.00177.x
PubMed: 21138536
PubMed Central: PMC4941650

Affiliations:

Links toward previous steps (curation, corpus...)

to stream Main, to step Corpus: 00428
to stream Main, to step Curation: 000428

Le document en format XML

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<term>Disease Models, Animal (MeSH)</term>
<term>Ferrets (immunology)</term>
<term>Ferrets (virology)</term>
<term>Hong Kong (epidemiology)</term>
<term>Humans (MeSH)</term>
<term>Influenza A Virus, H1N1 Subtype (genetics)</term>
<term>Influenza A Virus, H1N1 Subtype (immunology)</term>
<term>Influenza A Virus, H3N2 Subtype (genetics)</term>
<term>Influenza A Virus, H3N2 Subtype (immunology)</term>
<term>Influenza Vaccines (administration & dosage)</term>
<term>Influenza Vaccines (genetics)</term>
<term>Influenza Vaccines (immunology)</term>
<term>Influenza, Human (epidemiology)</term>
<term>Influenza, Human (immunology)</term>
<term>Influenza, Human (prevention & control)</term>
<term>Influenza, Human (virology)</term>
<term>Pandemics (MeSH)</term>
<term>Spain (epidemiology)</term>
<term>Vaccination (MeSH)</term>
<term>Vaccines, DNA (administration & dosage)</term>
<term>Vaccines, DNA (genetics)</term>
<term>Vaccines, DNA (immunology)</term>
<term>Viral Proteins (administration & dosage)</term>
<term>Viral Proteins (genetics)</term>
<term>Viral Proteins (immunology)</term>
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<term>Anticorps antiviraux (immunologie)</term>
<term>Espagne (épidémiologie)</term>
<term>Furets (immunologie)</term>
<term>Furets (virologie)</term>
<term>Grippe humaine (immunologie)</term>
<term>Grippe humaine (prévention et contrôle)</term>
<term>Grippe humaine (virologie)</term>
<term>Grippe humaine (épidémiologie)</term>
<term>Hong Kong (épidémiologie)</term>
<term>Humains (MeSH)</term>
<term>Modèles animaux de maladie humaine (MeSH)</term>
<term>Pandémies (MeSH)</term>
<term>Protéines virales (administration et posologie)</term>
<term>Protéines virales (génétique)</term>
<term>Protéines virales (immunologie)</term>
<term>Réactions croisées (MeSH)</term>
<term>Sous-type H1N1 du virus de la grippe A (génétique)</term>
<term>Sous-type H1N1 du virus de la grippe A (immunologie)</term>
<term>Sous-type H3N2 du virus de la grippe A (génétique)</term>
<term>Sous-type H3N2 du virus de la grippe A (immunologie)</term>
<term>Vaccination (MeSH)</term>
<term>Vaccins antigrippaux (administration et posologie)</term>
<term>Vaccins antigrippaux (génétique)</term>
<term>Vaccins antigrippaux (immunologie)</term>
<term>Vaccins à ADN (administration et posologie)</term>
<term>Vaccins à ADN (génétique)</term>
<term>Vaccins à ADN (immunologie)</term>
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<term>Vaccines, DNA</term>
<term>Viral Proteins</term>
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<keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>Influenza Vaccines</term>
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<term>Viral Proteins</term>
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<term>Vaccines, DNA</term>
<term>Viral Proteins</term>
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<term>Vaccins antigrippaux</term>
<term>Vaccins à ADN</term>
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<term>Influenza A Virus, H3N2 Subtype</term>
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<keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Protéines virales</term>
<term>Sous-type H1N1 du virus de la grippe A</term>
<term>Sous-type H3N2 du virus de la grippe A</term>
<term>Vaccins antigrippaux</term>
<term>Vaccins à ADN</term>
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<term>Furets</term>
<term>Grippe humaine</term>
<term>Protéines virales</term>
<term>Sous-type H1N1 du virus de la grippe A</term>
<term>Sous-type H3N2 du virus de la grippe A</term>
<term>Vaccins antigrippaux</term>
<term>Vaccins à ADN</term>
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<term>Influenza A Virus, H1N1 Subtype</term>
<term>Influenza A Virus, H3N2 Subtype</term>
<term>Influenza, Human</term>
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<keywords scheme="MESH" qualifier="virologie" xml:lang="fr"><term>Furets</term>
<term>Grippe humaine</term>
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<keywords scheme="MESH" qualifier="virology" xml:lang="en"><term>Ferrets</term>
<term>Influenza, Human</term>
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<keywords scheme="MESH" qualifier="épidémiologie" xml:lang="fr"><term>Espagne</term>
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<term>Humains</term>
<term>Modèles animaux de maladie humaine</term>
<term>Pandémies</term>
<term>Réactions croisées</term>
<term>Vaccination</term>
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<front><div type="abstract" xml:lang="en"><p><b>BACKGROUND</b>
</p>
<p>Alternative influenza vaccines and vaccine production forms are needed as the conventional protein vaccines do not induce broad cross-reactivity against drifted strains. Furthermore, fast vaccine production is especially important in a pandemic situation, and broader vaccine reactivity would diminish the need for frequent change in the vaccine formulations.</p>
</div>
<div type="abstract" xml:lang="en"><p><b>OBJECTIVE</b>
</p>
<p>In this study, we compared the ability of pandemic influenza DNA vaccines to induce immunity against distantly related strains within a subtype with the immunity induced by conventional trivalent protein vaccines against homologous virus challenge.</p>
</div>
<div type="abstract" xml:lang="en"><p><b>METHODS</b>
</p>
<p>Ferrets were immunised by particle-mediated epidermal delivery (gene gun) with DNA vaccines based on the haemagglutinin (HA) and neuraminidase (NA) and/or the matrix (M) and nucleoprotein genes of the 1918 H1N1 Spanish influenza pandemic virus or the 1968 H3N2 Hong Kong influenza pandemic virus. The animals were challenged with contemporary H1N1 or H3N2 viruses.</p>
</div>
<div type="abstract" xml:lang="en"><p><b>RESULTS</b>
</p>
<p>We demonstrated that DNA vaccines encoding proteins of the original 1918 H1N1 pandemic virus induced protective cross-reactive immune responses in ferrets against infection with a 1947 H1N1 virus and a recent 1999 H1N1 virus. Similarly, a DNA vaccine, based on the HA and NA of the 1968 H3N2 pandemic virus, induced cross-reactive immune responses against a recent 2005 H3N2 virus challenge.</p>
</div>
<div type="abstract" xml:lang="en"><p><b>CONCLUSIONS</b>
</p>
<p>DNA vaccines based on pandemic or recent seasonal influenza genes induced cross-reactive immunity against contemporary virus challenge as good as or superior to contemporary conventional trivalent protein vaccines. This suggests a unique ability of influenza DNA to induce cross-protective immunity against both contemporary and long-time drifted viruses.</p>
</div>
</front>
</TEI>
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<Month>03</Month>
<Day>08</Day>
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<DateRevised><Year>2018</Year>
<Month>11</Month>
<Day>13</Day>
</DateRevised>
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<Title>Influenza and other respiratory viruses</Title>
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<ArticleTitle>Pandemic influenza 1918 H1N1 and 1968 H3N2 DNA vaccines induce cross-reactive immunity in ferrets against infection with viruses drifted for decades.</ArticleTitle>
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<Abstract><AbstractText Label="BACKGROUND" NlmCategory="BACKGROUND">Alternative influenza vaccines and vaccine production forms are needed as the conventional protein vaccines do not induce broad cross-reactivity against drifted strains. Furthermore, fast vaccine production is especially important in a pandemic situation, and broader vaccine reactivity would diminish the need for frequent change in the vaccine formulations.</AbstractText>
<AbstractText Label="OBJECTIVE" NlmCategory="OBJECTIVE">In this study, we compared the ability of pandemic influenza DNA vaccines to induce immunity against distantly related strains within a subtype with the immunity induced by conventional trivalent protein vaccines against homologous virus challenge.</AbstractText>
<AbstractText Label="METHODS" NlmCategory="METHODS">Ferrets were immunised by particle-mediated epidermal delivery (gene gun) with DNA vaccines based on the haemagglutinin (HA) and neuraminidase (NA) and/or the matrix (M) and nucleoprotein genes of the 1918 H1N1 Spanish influenza pandemic virus or the 1968 H3N2 Hong Kong influenza pandemic virus. The animals were challenged with contemporary H1N1 or H3N2 viruses.</AbstractText>
<AbstractText Label="RESULTS" NlmCategory="RESULTS">We demonstrated that DNA vaccines encoding proteins of the original 1918 H1N1 pandemic virus induced protective cross-reactive immune responses in ferrets against infection with a 1947 H1N1 virus and a recent 1999 H1N1 virus. Similarly, a DNA vaccine, based on the HA and NA of the 1968 H3N2 pandemic virus, induced cross-reactive immune responses against a recent 2005 H3N2 virus challenge.</AbstractText>
<AbstractText Label="CONCLUSIONS" NlmCategory="CONCLUSIONS">DNA vaccines based on pandemic or recent seasonal influenza genes induced cross-reactive immunity against contemporary virus challenge as good as or superior to contemporary conventional trivalent protein vaccines. This suggests a unique ability of influenza DNA to induce cross-protective immunity against both contemporary and long-time drifted viruses.</AbstractText>
<CopyrightInformation>© 2010 Blackwell Publishing Ltd.</CopyrightInformation>
</Abstract>
<AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Bragstad</LastName>
<ForeName>Karoline</ForeName>
<Initials>K</Initials>
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<ForeName>Joakim S</ForeName>
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<Author ValidYN="Y"><LastName>Jensen</LastName>
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<Author ValidYN="Y"><LastName>Fomsgaard</LastName>
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<ArticleIdList><ArticleId IdType="pubmed">21138536</ArticleId>
<ArticleId IdType="doi">10.1111/j.1750-2659.2010.00177.x</ArticleId>
<ArticleId IdType="pmc">PMC4941650</ArticleId>
</ArticleIdList>
<ReferenceList><Reference><Citation>Virus Res. 2002 Jan 30;82(1-2):73-5</Citation>
<ArticleIdList><ArticleId IdType="pubmed">11885954</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Cell. 1982 Dec;31(2 Pt 1):417-27</Citation>
<ArticleIdList><ArticleId IdType="pubmed">6186384</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Bull Hist Med. 2002 Spring;76(1):105-15</Citation>
<ArticleIdList><ArticleId IdType="pubmed">11875246</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Curr Top Microbiol Immunol. 1985;114:177-255</Citation>
<ArticleIdList><ArticleId IdType="pubmed">2581739</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>DNA Cell Biol. 1993 Nov;12(9):799-805</Citation>
<ArticleIdList><ArticleId IdType="pubmed">8216851</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Leukoc Biol. 2000 Dec;68(6):793-806</Citation>
<ArticleIdList><ArticleId IdType="pubmed">11129646</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Virol. 2009 May;83(9):4624-30</Citation>
<ArticleIdList><ArticleId IdType="pubmed">19211745</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Science. 2005 Oct 7;310(5745):77-80</Citation>
<ArticleIdList><ArticleId IdType="pubmed">16210530</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>APMIS. 2006 Oct;114(10):690-9</Citation>
<ArticleIdList><ArticleId IdType="pubmed">17004972</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Trends Mol Med. 2006 May;12(5):216-22</Citation>
<ArticleIdList><ArticleId IdType="pubmed">16621717</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Virol. 1997 May;71(5):3391-6</Citation>
<ArticleIdList><ArticleId IdType="pubmed">9094608</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Virology. 1964 Dec;24:589-97</Citation>
<ArticleIdList><ArticleId IdType="pubmed">14240407</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Vaccine. 2009 Apr 21;27(18):2506-12</Citation>
<ArticleIdList><ArticleId IdType="pubmed">19368793</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Virol. 1989 Mar;63(3):1239-46</Citation>
<ArticleIdList><ArticleId IdType="pubmed">2915381</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Virus Res. 2005 May;109(2):181-90</Citation>
<ArticleIdList><ArticleId IdType="pubmed">15763149</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Nature. 2008 Sep 25;455(7212):532-6</Citation>
<ArticleIdList><ArticleId IdType="pubmed">18716625</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Proc Natl Acad Sci U S A. 1990 Jan;87(2):786-90</Citation>
<ArticleIdList><ArticleId IdType="pubmed">2300562</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Vet Immunol Immunopathol. 2009 Dec 15;132(2-4):109-15</Citation>
<ArticleIdList><ArticleId IdType="pubmed">19505731</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Acta Virol. 2009;53(1):15-20</Citation>
<ArticleIdList><ArticleId IdType="pubmed">19301946</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Virol J. 2008 Mar 07;5:40</Citation>
<ArticleIdList><ArticleId IdType="pubmed">18325125</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Virol. 2005 Dec;79(23):14933-44</Citation>
<ArticleIdList><ArticleId IdType="pubmed">16282492</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Vaccine. 2000 May 22;18(23):2592-9</Citation>
<ArticleIdList><ArticleId IdType="pubmed">10775793</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Virol. 2007 Aug;81(16):8593-600</Citation>
<ArticleIdList><ArticleId IdType="pubmed">17553891</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Vaccine. 2000 Aug 1;18(28):3214-22</Citation>
<ArticleIdList><ArticleId IdType="pubmed">10869766</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Expert Rev Vaccines. 2008 Mar;7(2):175-91</Citation>
<ArticleIdList><ArticleId IdType="pubmed">18324888</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Nat Rev Genet. 2008 Oct;9(10):776-88</Citation>
<ArticleIdList><ArticleId IdType="pubmed">18781156</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Biol Direct. 2006 Oct 26;1:34</Citation>
<ArticleIdList><ArticleId IdType="pubmed">17067369</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Am J Epidemiol. 1982 Oct;116(4):589-98</Citation>
<ArticleIdList><ArticleId IdType="pubmed">7137146</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>PLoS Med. 2007 Feb;4(2):e59</Citation>
<ArticleIdList><ArticleId IdType="pubmed">17298168</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>PLoS Pathog. 2009 Mar;5(3):e1000350</Citation>
<ArticleIdList><ArticleId IdType="pubmed">19300497</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Vaccine. 2005 Nov 16;23(46-47):5404-10</Citation>
<ArticleIdList><ArticleId IdType="pubmed">16011865</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Virology. 2002 Oct 10;302(1):44-57</Citation>
<ArticleIdList><ArticleId IdType="pubmed">12429515</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Proc Natl Acad Sci U S A. 1985 Mar;82(6):1785-9</Citation>
<ArticleIdList><ArticleId IdType="pubmed">3872457</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Nat Struct Mol Biol. 2009 Mar;16(3):265-73</Citation>
<ArticleIdList><ArticleId IdType="pubmed">19234466</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Proc Natl Acad Sci U S A. 2004 Mar 2;101(9):3166-71</Citation>
<ArticleIdList><ArticleId IdType="pubmed">14963236</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Virol. 1999 Mar;73(3):2094-8</Citation>
<ArticleIdList><ArticleId IdType="pubmed">9971791</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Nature. 1995 Jul 6;376(6535):92-4</Citation>
<ArticleIdList><ArticleId IdType="pubmed">7596443</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>BMC Infect Dis. 2010 Jan 07;10:5</Citation>
<ArticleIdList><ArticleId IdType="pubmed">20059763</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>AIDS Res Hum Retroviruses. 2000 Dec 10;16(18):1997-2008</Citation>
<ArticleIdList><ArticleId IdType="pubmed">11153083</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Vaccine. 2006 May 22;24(21):4475-81</Citation>
<ArticleIdList><ArticleId IdType="pubmed">16150518</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Vaccine. 2000 Jan 6;18(11-12):957-1030</Citation>
<ArticleIdList><ArticleId IdType="pubmed">10590322</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Clin Microbiol. 2002 Sep;40(9):3256-60</Citation>
<ArticleIdList><ArticleId IdType="pubmed">12202562</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Proc Natl Acad Sci U S A. 1999 Feb 16;96(4):1651-6</Citation>
<ArticleIdList><ArticleId IdType="pubmed">9990079</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Hum Gene Ther. 2006 Nov;17(11):1051-61</Citation>
<ArticleIdList><ArticleId IdType="pubmed">17032152</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Cochrane Database Syst Rev. 2007 Apr 18;(2):CD001269</Citation>
<ArticleIdList><ArticleId IdType="pubmed">17443504</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Vaccine. 2002 May 15;20 Suppl 2:S74-6</Citation>
<ArticleIdList><ArticleId IdType="pubmed">12110264</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
</PubmedData>
</pubmed>
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Pandemic influenza 1918 H1N1 and 1968 H3N2 DNA vaccines induce cross-reactive immunity in ferrets against infection with viruses drifted for decades.

Pandemic influenza 1918 H1N1 and 1968 H3N2 DNA vaccines induce cross-reactive immunity in ferrets against infection with viruses drifted for decades.

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